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KMID : 0370220070510060447
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Yakhak Hoeji
2007 Volume.51 No. 6 p.447 ~ p.454
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Synthesis of 6-(Thienylmethylene)penam Sulfones and their {beta}-Lactamase Inhibitory Activities
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Kim Dong-Hyeon
Pritam Thapa
Radha Karki
Jahng Yurng-Dong
Lee Eung-Seok
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Abstract
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The resistance of bacteria against {beta}-lactam antibiotics is mainly caused by the production of {beta}-lactamase enzymes. {beta}-Lactamase inhibitors are used in combination with known antibiotics to overcome the growing problem of bacterial resistance. We prepared 6-(thienylmethylene)penam sulfones for the development of potent {beta}-lactamase inhibitors and evaluated their {beta}-lactamase inhibitory activities.
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KEYWORD
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{beta}-lactamase inhibitor, sulbactam, bacterial resistance, 6-(thienylmethylene)penam sulfone
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